Traditionally used for gastrointestinal symptoms, berberine has emerged as a potent cardiometabolic aid with diverse benefits and mechanisms of action. It has hypoglycemic effects, via both an inhibition of alpha-glucosidase activity and an upregulation of insulin receptors in peripheral tissues, thereby improving insulin sensitivity.1,2 Furthermore, it activates Nrf2, a key regulator of cellular antioxidant defense, and attenuates glucose induced neurotoxicity, suggesting a therapeutic potential for diabetic neuropathy.3

In controlled trials it reduced HbA1c levels in diabetic participants with comparable efficacy to metformin. Among participants with the metabolic syndrome it has been shown to reduce waist circumference and body weight, blood pressure, triglycerides, and improve insulin resistance compared to placebo, with similar benefits in women with PCOS.4,5 Berberine targets multiple cardiometabolic risk factors, as it has been shown to also lower total and LDL cholesterol among diabetic participants in several controlled trials.6,7 Additionally, a clinical trial comparing standard therapy with or without berberine among patients receiving percutaneous coronary intervention showed improvements in multiple inflammatory markers, including C-reactive protein, IL-6, MMP-9, ICAM-1, and VCAM-1.8

传统上用于胃肠道症状的小檗碱已经成为一种有效的心脏代谢辅助药物,具有多种益处和作用机制。它具有降血糖作用,通过抑制α-葡萄糖苷酶活性和外周组织中胰岛素受体的上调,从而改善胰岛素敏感性.1,2此外,它还能激活细胞抗氧化防御的关键调节因子Nrf2,并减弱葡萄糖诱导的作用。神经毒性,提示糖尿病神经病变的治疗潜力 在对照试验中,它降低了糖尿病患者的HbA1c水平,其疗效与二甲双胍相当。在患有代谢综合征的参与者中,与安慰剂相比,已显示出减少腰围和体重,血压,甘油三酯和改善胰岛素抵抗,PCOS女性具有相似的益处.4小檗碱靶向多种心脏代谢风险因素,如在几项对照试验中,糖尿病患者的总胆固醇和低密度脂蛋白胆固醇也有所降低[6,7]。此外,在接受经皮冠状动脉介入治疗的患者中进行的标准治疗与或不使用小檗碱的临床试验表明多种炎症标志物的改善,包括C-反应蛋白,IL-6,MMP-9,ICAM-1和VCAM-1.8

Medicinal Ingredients

Serving Size: 1 Vegetarian Capsule
Servings per Container: 90

Each Vegetarian Capsule Contains:
Berberine (Hydrochloride) (Berberis vulgaris) (root).........500 mg

药用成分: 每个素食胶囊包含: 小檗碱(盐酸盐)(Berberis vulgaris)(根)......... 500 mg

Recommended Use:

1 capsule 2 times per day with meals or as directed by a health care practitioner. Consult a health care practitioner for use beyond 3 months.


建议用量: 每日2次,每次2粒,随餐或按照医疗保健医生的指示。若服用超过3个月, 请咨询保健医生。

Berberine HCL

庫存單位: C133
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