In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol.1 In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.2 As such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.3 Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.4 Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5 It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.

一般来说,雌激素可分为几种生物化学上不同的激素:雌酮(E1),雌二醇(E2),雌三醇(E3)和17β-雌二醇.1在绝经前妇女中,雌激素被酶促转化为几种特定的雌激素代谢物,包括2-羟基雌酮(2-OHE1),2-羟基雌二醇(2-OHE2),4-羟基雌酮(4-OHE1),4-羟基雌二醇(4-OHE2)和16α-羟基雌酮(16α-OHE1)。 16α-OHE1和2-OHE在细胞水平上具有对比的生物活性,16α-OHE1是雌激素激动剂和增殖剂,而2-OHE是雌激素拮抗剂和抗增殖剂. 因此,2-OHE比例增加:16α -OHE1与绝经前女性患乳腺癌风险降低的风险相关.3 EstroVantage EM中发现的几种天然产物支持后者的概念,包括DIM和吲哚3甲醇(I3C)。一项人体研究证实,每天每天补充300毫克的I3C,持续12周,显着增加2-OH-雌酮:雌三醇代谢物的比例而没有明显的不良事件.4 EstroVantage EM中的其他化合物,包括钙-d-葡萄糖酸盐,抑制β - 葡萄糖醛酸酶活性,允许在重吸收前排泄雌激素。据估计,4%的葡萄糖酸钙补充饮食可使β-葡萄糖醛酸酶活性抑制70%.

Each Vegetarian Capsule Contains:  
Calcium D-Glucarate (d-Glucaric Acid Calcium Salt) 75 mg
Indole-3-Carbinol (3-Hydroxymethylindole) 75 mg
Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine) 50 mg
Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene) 50 mg
Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane) 27.5 mg
DIM (3,3’-Diindolylmethane) 25 mg
Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids) 25 mg
Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin) 25 mg
Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf) 12.5 mg
* Epigallocatechin-3-gallate

 

每个素食胶囊包含:

D-葡萄糖酸钙(d-葡糖二酸钙盐)75 mg

吲哚-3-甲醇(3-羟甲基吲哚)75mg

绿茶提取物(叶)(80%儿茶素,45%EGCG *,<1%咖啡因)50毫克

番茄提取物(水果)(5%番茄红素)50毫克

西兰花粉(0.36%Sulforaphane)27.5毫克

DIM(3,3'-二吲哚基甲烷)25mg

姜黄提取物(根茎)(95%姜黄素)25毫克

牛奶蓟萃取物(水飞蓟)(种子)25毫克

迷迭香6:1提取物(迷迭香属)(叶子)12.5毫克 

Recommended Use:

3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.

建议用量: 每天一次,每次3粒,食物或按照医疗保健医生的指示。若服用超过12周,请咨询保健医生。

EstroVantage EM

庫存單位: C134
C$67.30價格
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