In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol.1 In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.2 As such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.3 Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.4 Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5 It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.
一般来说，雌激素可分为几种生物化学上不同的激素：雌酮（E1），雌二醇（E2），雌三醇（E3）和17β-雌二醇.1在绝经前妇女中，雌激素被酶促转化为几种特定的雌激素代谢物，包括2-羟基雌酮（2-OHE1），2-羟基雌二醇（2-OHE2），4-羟基雌酮（4-OHE1），4-羟基雌二醇（4-OHE2）和16α-羟基雌酮（16α-OHE1）。 16α-OHE1和2-OHE在细胞水平上具有对比的生物活性，16α-OHE1是雌激素激动剂和增殖剂，而2-OHE是雌激素拮抗剂和抗增殖剂. 因此，2-OHE比例增加：16α -OHE1与绝经前女性患乳腺癌风险降低的风险相关.3 EstroVantage EM中发现的几种天然产物支持后者的概念，包括DIM和吲哚3甲醇（I3C）。一项人体研究证实，每天每天补充300毫克的I3C，持续12周，显着增加2-OH-雌酮：雌三醇代谢物的比例而没有明显的不良事件.4 EstroVantage EM中的其他化合物，包括钙-d-葡萄糖酸盐，抑制β - 葡萄糖醛酸酶活性，允许在重吸收前排泄雌激素。据估计，4％的葡萄糖酸钙补充饮食可使β-葡萄糖醛酸酶活性抑制70％.
| Each Vegetarian Capsule Contains: | |
| Calcium D-Glucarate (d-Glucaric Acid Calcium Salt) | 75 mg |
| Indole-3-Carbinol (3-Hydroxymethylindole) | 75 mg |
| Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine) | 50 mg |
| Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene) | 50 mg |
| Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane) | 27.5 mg |
| DIM (3,3’-Diindolylmethane) | 25 mg |
| Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids) | 25 mg |
| Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin) | 25 mg |
| Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf) | 12.5 mg |
| * Epigallocatechin-3-gallate |
每个素食胶囊包含：
D-葡萄糖酸钙（d-葡糖二酸钙盐）75 mg
吲哚-3-甲醇（3-羟甲基吲哚）75mg
绿茶提取物（叶）（80％儿茶素，45％EGCG *，<1％咖啡因）50毫克
番茄提取物（水果）（5％番茄红素）50毫克
西兰花粉（0.36％Sulforaphane）27.5毫克
DIM（3,3'-二吲哚基甲烷）25mg
姜黄提取物（根茎）（95％姜黄素）25毫克
牛奶蓟萃取物（水飞蓟）（种子）25毫克
迷迭香6：1提取物（迷迭香属）（叶子）12.5毫克
Recommended Use:
3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.
建议用量： 每天一次，每次3粒，食物或按照医疗保健医生的指示。若服用超过12周，请咨询保健医生。
EstroVantage EM
Free Shipping.